Local axon collaterals of area CA1 support spread of epileptiform discharges within CA1, but propagation is unidirectional

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Local axon collaterals of area CA1 support spread of epileptiform discharges within CA1, but propagation is unidirectional.

CA3 and subiculum are hippocampal formation regions that can initiate seizure activity because each has a substantial intrinsic excitatory connectivity. We studied the intrinsic connectivity of area CA1 by exploring the spread of synchronous population discharges in ventral hippocampal slices from rats using a recording chamber that permitted multiple simultaneous extracellular recordings along...

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Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons.

A paroxysmal depolarization shift (PDS) has been suggested to be a hallmark for epileptic activity in partial-onset seizures. By monitoring membrane potentials and currents in pairs of pyramidal neurons and astrocytes with dual patch-clamp recording and exocytosis of vesicles from astrocytes with two-photon laser scanning microscopy in hippocampal slices, we found that infusion of inositol 1,4,...

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Assessment of the effect of nitric oxide within hippocampal CA1 area on spatial learning and memory in morphine dependent rats

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ژورنال

عنوان ژورنال: Hippocampus

سال: 2008

ISSN: 1050-9631,1098-1063

DOI: 10.1002/hipo.20460